Related Experiment Video
Updated: Aug 18, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
Pudendal neuralgia, a severe pain syndrome
Jesse Thomas Benson1, Kenneth Griffis
1Department of Obstetrics and Gynecology, Indiana University/Methodist Hospital, Indianapolis, USA.
Objective:
To describe the clinical and electrodiagnostic findings, therapies, and outcomes of patients with pudendal neuralgia.
Study Design:
A retrospective, descriptive study of 64 patients from March 19 to December 22, 2003.
Results:
Clinical findings included pain along nerve distribution (64, 100%), pain aggravated by sitting (62, 97%), pain relieved by standing or lying (57, 89%), and misdiagnosis (53, 83%). Neurophysiologic findings were normal (23, 35%), demyelination (17, 26%), axonal loss (5, 7.5%), and demyelination with axonal loss (21, 32%). Therapies were conservative (64, 100%), nerve injection (38, 59%), neuromodulation (2, 3%), and decompression surgery (10, 15%). Slight or moderate pain improvement with therapies included conservative (64, 100%), nerve injection (12, 31%), neuromodulation (2, 100%), and decompression (6, 60%).
Conclusion:
Pudendal neuralgia is poorly recognized and poorly treated. Improvement is gained with conservative therapy. Injections and decompression benefit one half and one third of patients, respectively. Neuromodulation needs further evaluation.
Related Concept Videos
Spinal Nerves: Plexus II
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
Pain
Degenerative Disc Disease ll: Pathophysiology
Diabetic Neuropathy
Nociception
Analgesia and Pain Management