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Updated: Aug 18, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
[Platelet inhibition and activation. Mechanisms and clinical implications]
Lorenzo Alberio1, Kenneth J Clemetson
1Klinik und Poliklinik für Hämatologie und Hämatologisches Zentrallabor der Universität, Inselspital, Bern, Schweiz.
Abstract:
The sensitivity to activation of platelets is part of the delicate equilibrium differentiating hemostasis from thrombosis. Under physiological conditions it is maintained by downregulating platelet activity and removing agonists. Under pathologic conditions the clinician tries to restore this equilibrium with pharmaceutical drugs. The results obtained by such treatments are steadily improving but there is still need for better knowledge of the mechanisms involved and for alternative inhibitors.
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