Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bronchodilators in chronic obstructive pulmonary disease (COPD)].

Adrian Gillissen1, Roland Buhl, Klaus Friedrich Rabe

  • 1Robert-Koch-Klinik, Klinikum "St. Georg", Leipzig. adrian.gillissen@sanktgeorg.de

Medizinische Klinik (Munich, Germany : 1983)
|May 20, 2005
PubMed
Summary

Long-acting bronchodilators are recommended for early chronic obstructive pulmonary disease (COPD) treatment. Combining therapies and inhaled corticosteroids in later stages improve lung function and quality of life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Lung transplantation, a contemporary review for the general parctitioner].

MMW Fortschritte der Medizin·2026
Same author

Outcomes and risk factors for mortality in patients with pulmonary non-tuberculous mycobacterial infections: A single-center retrospective cohort study.

Pneumologie (Stuttgart, Germany)·2026
Same author

Aerosol therapy during noninvasive ventilation (NIV) and nasal high-flow therapy (HFT): current technology and consensus-based recommendations.

Pneumologie (Stuttgart, Germany)·2026
Same author

MMW Fortschritte der Medizin·2026
Same author

[Diagnostik und Therapie bronchopleuraler und bronchoalveolärer Fistel].

Pneumologie (Stuttgart, Germany)·2026
Same author

MMW Fortschritte der Medizin·2026

Area of Science:

  • Pulmonary Medicine
  • Pharmacotherapy
  • Clinical Trials

Background:

  • Bronchodilators are foundational in managing chronic obstructive pulmonary disease (COPD).
  • Choosing optimal bronchodilator therapy is complex due to numerous drug classes, mechanistic differences, and fixed combinations.
  • Clinical trial data guides treatment decisions for COPD patients.

Purpose of the Study:

  • To review clinical efficacy of various bronchodilator classes in COPD.
  • To establish effective disease management objectives.
  • To propose an evidence-based treatment algorithm for COPD pharmacotherapy.

Main Methods:

  • Review of large, double-blind clinical trials.
  • Evaluation of anticholinergic drugs, long- and short-acting beta(2)-agonists, and xanthines.

Related Experiment Videos

  • Assessment of different application forms and drug combinations.

    • Main Results:

    • Inhalation therapy with long-acting bronchodilators (e.g., tiotropium, formoterol, salmeterol) is proposed for early COPD treatment.
    • Combination therapy of anticholinergics and long-acting bronchodilators may offer additive bronchodilatory effects.
    • Inhaled corticosteroids are recommended only for stages III and IV COPD.

    Conclusions:

    • Early treatment algorithms for COPD should prioritize long-acting bronchodilators.
    • Pharmacotherapy for COPD requires a comprehensive approach including smoking cessation and supportive care.
    • Optimizing bronchodilator selection and combination improves lung function, reduces exacerbations, and enhances quality of life in COPD patients.