Related Experiment Video
Updated: Aug 18, 2026
09:23
Combining Double Fluorescence In Situ Hybridization with Immunolabelling for Detection of the Expression of Three Genes in Mouse Brain Sections
Published on: March 26, 2016
Absolute configuration of N-acetylaspartate in urine from patients with Canavan disease
D Bal1, A Gryff-Keller, W Gradowska
1Warsaw University of Technology, Faculty of Chemistry, Warsaw, Poland. domibal@yahoo.co.uk
Journal of Inherited Metabolic Disease
|May 20, 2005
Abstract:
High-resolution 1H and 13C NMR of N-acetylaspartic acid as its 2-(S)-butyl diester allows the two enantiomers to be unambiguously identified. Analysis of urine samples from five patients with Canavan disease (N-aspartoacylase deficiency) showed that more than 95% of the excreted N-acetylaspartate had the S-configuration.
