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Changes in gastrointestinal function attributed to aging.

R M Russell1

  • 1US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.

The American Journal of Clinical Nutrition
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

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Aging impacts gastrointestinal (GI) function, affecting nutrient absorption and leading to changes like reduced taste and stomach acid. Further research is needed on these GI changes and their health implications in older adults.

Area of Science:

  • Gastroenterology
  • Gerontology
  • Human Physiology

Background:

  • Aging is associated with numerous reports of impaired gastrointestinal (GI) function.
  • However, the intestine, pancreas, and liver possess significant reserve capacity, maintaining many GI functions.
  • Clinically relevant age-related GI changes in humans include diminished taste sensitivity, hypochlorhydria from atrophic gastritis, and reduced liver blood flow.

Purpose of the Study:

  • To review age-related changes in gastrointestinal function.
  • To identify specific nutrients with impaired bioavailability in aging individuals.
  • To highlight the need for further study on the health implications of these GI changes in the elderly.

Main Methods:

  • Literature review of studies on aging and gastrointestinal function.

Related Experiment Videos

  • Analysis of age-related changes in nutrient absorption, including lipids and large molecules.
  • Examination of clinically significant functional changes in the aging human GI tract.

    • Main Results:

    • While many GI functions remain intact, specific changes occur with aging, such as decreased taste thresholds and hypochlorhydria.
    • Impaired bioavailability of nutrients like vitamin B-12, calcium, iron, and zinc is observed in aging populations.
    • Increased absorption of lipids and large molecules in aging animals warrants further investigation in humans.

    Conclusions:

    • Aging induces specific, clinically relevant changes in human gastrointestinal function.
    • These changes can affect nutrient bioavailability, potentially impacting health in older adults.
    • The long-term health implications of age-related GI alterations require comprehensive study.