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Related Experiment Videos

Aripiprazole (abilify) overdose in a child.

Steven A Seifert1, Michael D Schwartz, Jerry D Thomas

  • 1Nebraska Regional Poison Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Clinical Toxicology (Philadelphia, Pa.)
|May 21, 2005
PubMed
Summary

Aripiprazole overdose in a young child caused central nervous system depression lasting nearly two weeks. Fortunately, the child experienced no significant cardiovascular effects or need for respiratory support.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Toxicology

Background:

  • Aripiprazole is a third-generation atypical antipsychotic and a partial dopamine agonist.
  • It is known for its long elimination half-life and variable metabolism due to genetic polymorphism.

Observation:

  • An unintentional overdose of 195 mg (17.1 mg/kg) of aripiprazole was administered to a 2.5-year-old child.
  • The child presented with central nervous system (CNS) depression.

Findings:

  • The CNS depression did not necessitate respiratory support.
  • No significant cardiovascular effects were observed.
  • CNS effects persisted for nearly two weeks post-ingestion.

Implications:

  • This case highlights the potential for CNS depression in pediatric aripiprazole overdose.

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  • The prolonged CNS effects underscore the importance of monitoring in such cases.
  • Further research into pediatric pharmacokinetics and toxicology of atypical antipsychotics is warranted.