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Updated: Aug 18, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
Published on: June 14, 2015
Double-patch repair of postinfarction ventricular septal defect
Mehmet Balkanay1, Ercan Eren, Cuneyt Keles
1Department of Cardiovascular Surgery, Kosuyolu Heart and Research Hospital, Istanbul, Turkey.
Abstract:
We report 4 consecutive cases in which the double-patch technique was used to repair an inferior postinfarction ventricular septal rupture. The ventricular septal perforation was closed directly by stitching, with the same sutures, 2 autologous pericardial patches onto both sides of the affected septum, through only a left ventriculotomy. Complete closure of the defect was accomplished, and no residual shunt was observed in any patient. This technique appears to be useful in selected cases, such as ventricular septal perforation with myocardial infarction in the subacute or chronic phase, especially in instances of inferoposterior infarction. Further experience is needed to verify its safety and efficacy.

