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Related Experiment Videos

Protein-losing enteropathy with collagenous colitis.

M E Stark1, K P Batts, G L Alexander

  • 1Division of Gastroenterology, Mayo Clinic and Foundation, Rochester, Minnesota.

The American Journal of Gastroenterology
|June 1, 1992
PubMed
Summary

Collagenous colitis, a cause of chronic diarrhea, can be linked to protein-losing enteropathy. This case highlights the importance of colonic biopsies in diagnosing unexplained protein loss.

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Area of Science:

  • Gastroenterology
  • Pathology

Background:

  • Collagenous colitis is a rare cause of chronic watery diarrhea.
  • It is characterized by subepithelial collagen deposition in the colon.
  • Enteric protein loss is not a typical feature.

Observation:

  • A 62-year-old woman presented with collagenous colitis.
  • She also exhibited marked protein-losing enteropathy.
  • No obvious small intestinal disease or colonic ulceration was found.

Findings:

  • The patient's collagenous colitis was associated with significant protein loss.
  • This association is uncommon and not widely recognized.
  • Biopsies revealed collagen deposition in the colonic mucosa.

Implications:

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  • This case suggests a potential link between collagenous colitis and protein-losing enteropathy.
  • Endoscopically normal colonic biopsies are crucial for diagnosing unexplained protein loss.
  • Further research may elucidate the mechanisms connecting these conditions.