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Related Experiment Videos

Assisted reproductive technologies and birth defects.

Kohei Shiota1, Shigehito Yamada

  • 1Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan. shiota@anat1.med.kyoto-u.ac.jp

Congenital Anomalies
|May 21, 2005
PubMed
Summary
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Assisted reproductive technologies (ART), like in vitro fertilization (IVF), may increase risks for major malformations and imprinting disorders in babies. Further research is needed to understand these potential risks associated with ART procedures.

Area of Science:

  • Reproductive Medicine
  • Developmental Biology
  • Genetics

Background:

  • Assisted reproductive technologies (ART), including in vitro fertilization (IVF), are common infertility treatments.
  • While generally safe, ART has been linked to potential adverse outcomes in offspring.
  • Recent studies suggest associations between ART and imprinting disorders.

Purpose of the Study:

  • To review existing human and animal studies on the potential risks of ART for offspring.
  • To discuss the implications of ART on major malformations, perinatal complications, and imprinting disorders.
  • To highlight the need for continued investigation into ART safety.

Main Methods:

  • Comprehensive review of human and animal studies.
  • Analysis of data on major malformations, low birth-weight, perinatal complications, and imprinting disorders.

Related Experiment Videos

  • Synthesis of findings regarding risks associated with IVF and intracytoplasmic sperm injection (ICSI).

    • Main Results:

    • Some studies indicate an increased occurrence of major malformations and low birth-weight in ART-conceived infants.
    • ART, specifically IVF and ICSI, has been associated with imprinting disorders like Beckwith-Wiedemann and Angelman syndromes.
    • Evidence from both human and animal studies warrants further examination.

    Conclusions:

    • ART procedures, while beneficial for infertility, may carry potential risks for offspring health.
    • Further research is crucial to fully elucidate and mitigate the risks associated with ART.
    • Understanding these risks is essential for improving ART safety and outcomes.