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Related Experiment Videos

Olfactory classical conditioning in newborn mice.

Myriam Bouslama1, Estelle Durand, Laetitia Chauvière

  • 1INSERM U676, Robert-Debré Teaching Hospital, 48 Boulevard Sérurier, 75019 Paris, France. mimistique@aol.com

Behavioural Brain Research
|May 21, 2005
PubMed
Summary
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Newborn mice can learn associations using a simple conditioning method from birth. This technique helps study gene function in early cognitive development and disorders.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Behavioral Genetics

Background:

  • Assessing the behavioral phenotype of genetically modified mice is crucial for understanding gene function and cognitive disorders.
  • Current methods for phenotyping newborn mice are limited, primarily focusing on sensorimotor reflexes.

Purpose of the Study:

  • To introduce a straightforward classical conditioning paradigm for evaluating associative learning in newborn mice.
  • To determine the earliest age at which newborn mice exhibit associative abilities.

Main Methods:

  • A two-odor choice classical conditioning paradigm was employed in mice from post-natal day 0 (P0) to P6.
  • Pups underwent 20 acquisition trials involving pairing a conditioned stimulus (CS+) odor with gentle stroking, followed by 5 odor-preference trials.

Related Experiment Videos

  • Conditioned odor preference was assessed immediately post-acquisition and after 5 and 24-hour retention intervals.

    • Main Results:

    • Newborn mice demonstrated a significant preference for the CS+ odor immediately after conditioning (p<0.0001).
    • No extinction of the conditioned preference was observed during the immediate post-acquisition test.
    • The conditioned odor preference was not retained after 5 or 24 hours, indicating rapid loss of the response.

    Conclusions:

    • Associative learning and conditioning are possible in mice as early as P0-P1, earlier than previously reported.
    • This simple conditioning paradigm is suitable for high-throughput phenotyping of genetically altered mice.
    • The method offers a valuable tool for investigating the role of genes in pediatric cognitive impairments.