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Updated: Aug 17, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
Two-chamber intracardiac mesothelioma
Hutan Ashrafian1, Thanos Athanasiou, John Yap
1Department of Cardiothoracic Surgery, St Mary's & Royal Brompton Hospital, London, England, United Kingdom.
Abstract:
Primary intracardiac malignant mesotheliomas are extremely rare and carry a very poor prognosis. We present such a case where the lesion encompassed two chambers, the left atrium and ventricle, with no pericardial involvement. Initial echocardiography mimicked a myxoma, and urgent surgical intervention was required in view of significant cardiorespiratory compromise. To the best of our knowledge this is the first case of a primary two-chamber intracardiac malignant sarcomatoid mesothelioma.
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