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Related Experiment Videos

Interaction study between enoxacin and fluvoxamine.

Toshiki Kunii1, Takashi Fukasawa, Norio Yasui-Furukori

  • 1Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan.

Therapeutic Drug Monitoring
|May 21, 2005
PubMed
Summary
This summary is machine-generated.

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Enoxacin, a CYP1A2 inhibitor, slightly increased fluvoxamine (FLV) plasma concentrations and enhanced FLV-induced sleepiness. Caution is advised when combining enoxacin with FLV due to potential drug interactions.

Area of Science:

  • Pharmacology
  • Drug Metabolism
  • Clinical Pharmacology

Background:

  • Cytochrome P4501A2 (CYP1A2) plays a crucial role in drug metabolism.
  • Enoxacin is a known inhibitor of CYP1A2.
  • Fluvoxamine (FLV) is a substrate of CYP1A2.

Purpose of the Study:

  • To investigate the pharmacokinetic and pharmacodynamic interaction between enoxacin and fluvoxamine (FLV).
  • To determine if enoxacin affects the metabolism and effects of FLV.

Main Methods:

  • Double-blind, randomized, crossover study in 10 healthy male volunteers.
  • Administration of enoxacin (200 mg/d) or placebo for 11 days.
  • Single 50-mg oral dose of FLV on day 8, with blood sampling and pharmacodynamic assessments up to 72 hours.

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Main Results:

  • Enoxacin significantly increased plasma concentrations of FLV at 2 and 3 hours, and Cmax.
  • No significant effect of enoxacin on the plasma concentration or pharmacokinetics of the FLV metabolite, fluvoxamino acid (FLA).
  • Enoxacin significantly increased Stanford Sleepiness Scale scores, indicating enhanced FLV-induced sleepiness.

Conclusions:

  • Enoxacin exhibits a slight inhibition of FLV metabolism.
  • Concomitant use of enoxacin and FLV may lead to increased FLV exposure and effects.
  • Caution is recommended when prescribing enoxacin and FLV together.