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Relationship between QT interval and cardiovascular risk factors in healthy young subjects

G Leotta1, S Maule, F Rabbia

  • 1Department of Medicine and Experimental Oncology, Hypertension Unit, Ospedale S. Vito, University of Turin, Strada San Vito 34, 10133 Turin, Italy. centroiperten.torino@libero.it

Journal of Human Hypertension
|May 21, 2005
PubMed

Insights

Prolonged corrected QT interval (QTc) is linked to cardiovascular risk factors like blood glucose and blood pressure, even in young adults. QT measurements may aid early cardiovascular risk screening in youth.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Electrocardiography

Background:

  • Prolonged QT interval is a known risk factor for cardiovascular events in specific populations.
  • Previous studies linked QT prolongation to cardiovascular risk factors in middle-aged and elderly individuals.

Purpose of the Study:

  • To determine the prevalence of prolonged corrected QT interval (QTc) in healthy young adults.
  • To explore the association between QTc, QT dispersion (QTd), and cardiovascular risk factors in this demographic.

Main Methods:

  • Evaluated 170 healthy young adults (ages 22-25).
  • Assessed QTc and QTd in relation to body mass index, blood pressure, glucose, cholesterol, smoking, and family history of hypertension.
  • Utilized multiple regression analysis to identify significant relationships.

Main Results:

  • A prolonged QTc was found in 10% of females and 5% of males.
  • QTc showed a positive correlation with blood glucose in females and systolic blood pressure in males.
  • QTd did not show significant associations with any studied cardiovascular risk factors.

Conclusions:

  • The link between QTc length, blood glucose, and blood pressure exists even in young, healthy individuals.
  • QT interval measurement could serve as a valuable tool for cardiovascular risk screening in younger populations.
  • Early identification of cardiovascular risk factors in youth is crucial for prevention.

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