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An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

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[Vesicorenal reflux].

¹Abteilung für Urologie und Kinderurologie im Urologischen Zentrum Hamburg (UZH), Allgemeines Krankenhaus Harburg, Hamburg.

Der Urologe. Ausg. A

|May 21, 2005

Summary

This summary is machine-generated.

Vesicorenal reflux affects 16-17% of children, primarily girls, often caused by ascending infections. Treatment options include watchful waiting with antibiotic prophylaxis or surgical repair for high-risk cases, with surgery showing high success rates.

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A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

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Published on: December 20, 2014

Area of Science:

Pediatric Urology
Nephrology
Infectious Diseases

Context:

Vesicorenal reflux (VRR) affects 16-17% of children, with ascending infections as the primary pathomechanism.
VRR is diagnosed in up to 70% of children experiencing febrile urinary tract infections.
Girls are disproportionately affected (85%), except in antenatally detected cases.

Purpose:

To outline the incidence, diagnosis, and management strategies for vesicorenal reflux in pediatric patients.
To discuss indications for conservative versus operative treatment, emphasizing spontaneous resolution probabilities.
To evaluate the efficacy and considerations for surgical intervention and endoscopic alternatives.

Summary:

Spontaneous resolution of VRR is more likely in low-grade, unilateral cases within the first year of life.
Conservative management with antibiotic prophylaxis is recommended during the maturation period to prevent urinary tract infections.
Surgical repair is indicated for breakthrough infections, high-grade reflux, renal function loss, malformations, or poor compliance, with surgery demonstrating >90% success rates.

Impact:

Informs clinical decision-making regarding the optimal timing and approach for VRR management in children.
Highlights the importance of considering surgical intervention more frequently in girls due to higher risks.
Provides insights into the comparative success rates of surgical repair versus endoscopic alternatives.