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Pure eccentric exercise does not activate blood coagulation.

Thomas Hilberg1, Doreen Gläser, Dagmar Prasa

  • 1Department of Sports Medicine, Friedrich-Schiller-University Jena, Wöllnitzerstr. 42, 07749 Jena, Germany. thomas.hilberg@uni-jena.de

European Journal of Applied Physiology
|May 21, 2005
PubMed
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Eccentric exercise, despite causing muscle damage, does not activate blood coagulation. Unlike cycle exercise, it showed no significant changes in thrombin potential or generation markers.

Area of Science:

  • Exercise Physiology
  • Hemostasis and Thrombosis
  • Skeletal Muscle Biology

Background:

  • Eccentric exercise can induce skeletal muscle damage, inflammation, and proteolytic activity.
  • These changes raise the possibility of triggering in vivo blood coagulation.
  • Investigating this link is crucial for understanding exercise-induced physiological responses.

Purpose of the Study:

  • To investigate changes in blood coagulation markers after pure eccentric exercise.
  • To compare these changes with those observed after cycle ergometry and a control condition.
  • To determine if the mechanical impact of eccentric exercise activates blood coagulation.

Main Methods:

  • Seventeen healthy males performed pure eccentric down jumps, cycle exercise, and a control experiment.

Related Experiment Videos

  • Blood samples were analyzed for activated partial thromboplastin time (aPTT), thrombin potential (TTP, ETP), and thrombin generation markers (F1+2, TAT).
  • Measurements were taken at rest, immediately post-exercise, and 2 hours post-exercise.

    • Main Results:

    • Cycle exercise significantly shortened aPTT and increased thrombin potential (TTPin) and thrombin-antithrombin complex (TAT).
    • Pure eccentric exercise resulted in minimal changes in aPTT and thrombin potential (TTPin, ETPin).
    • No significant thrombin generation (F1+2, TAT) was observed after eccentric exercise.

    Conclusions:

    • Pure eccentric exercise, despite inducing skeletal muscle damage, does not activate blood coagulation.
    • In contrast to concentric dynamic exercise, eccentric exercise does not lead to significant changes in thrombin potential or generation.
    • The mechanical impact of eccentric exercise alone does not appear to trigger a pro-coagulant response.