Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional radiochemotherapy using in situ hydrogel.

Ali Azhdarinia1, David J Yang, Dong-Fang Yu

  • 1Division of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. aazhdari@di.mdacc.tmc.edu

Pharmaceutical Research
|May 21, 2005
PubMed
Summary

This study shows that a hydrogel can effectively deliver chemotherapy drugs and radiation for mammary tumors. This localized treatment approach shows promise for inoperable tumors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fibulin-4 expressed in metastatic breast cancer is a target of peptide-based imaging probes and experimental therapeutics.

Molecular therapy. Oncology·2026
Same author

Investigating machine learning algorithms to classify label-free images of pancreatic neuroendocrine neoplasms.

Biophotonics discovery·2026
Same author

RBM39 Contributes to MGMT Maintenance in Response to Temozolomide-Induced DNA Damage.

Cancers·2025
Same author

Somatostatin Receptor 2 Overexpression in Hepatocellular Carcinoma: Implications for Cancer Biology and Therapeutic Applications.

Current oncology (Toronto, Ont.)·2025
Same author

Fibulin-4 is highly expressed in metastatic breast cancer and can serve as a target of peptide-based imaging probes and experimental therapeutics.

bioRxiv : the preprint server for biology·2025
Same author

Extrapleural Pneumonectomy for Treatment of Pulmonary Adenoid Cystic Carcinoma.

Annals of thoracic surgery short reports·2025

Area of Science:

  • Biomedical Engineering
  • Radiochemistry
  • Oncology

Background:

  • Mammary tumors pose a significant treatment challenge.
  • Regional chemotherapy and radiotherapy offer localized treatment options.
  • Hydrogels show potential for controlled drug and radioisotope delivery.

Purpose of the Study:

  • To assess the feasibility of a novel in situ hydrogel for regional radiochemotherapy of mammary tumors.
  • To evaluate the co-delivery of cisplatin (CDDP) and rhenium-188 ((188)Re) using a hydrogel system.
  • To investigate the therapeutic efficacy and safety of this localized treatment in a preclinical model.

Main Methods:

  • Sodium alginate hydrogels were formulated for co-delivery of CDDP and (188)Re.
  • In vitro studies assessed (188)Re-hydrogel cytotoxicity and CDDP-hydrogel sustained release.

Related Experiment Videos

  • In vivo studies in tumor-bearing rats involved intratumoral injection of hydrogels and imaging.

    • Main Results:

    • In vitro studies confirmed hydrogel integrity, (188)Re cytotoxicity, and sustained CDDP release.
    • In vivo studies demonstrated significant delay in tumor growth in treated groups compared to controls.
    • Scintigraphic imaging confirmed hydrogel localization within the tumor site for up to 48 hours post-injection with minimal impact on kidney function.

    Conclusions:

    • Hydrogel-based delivery of chemotherapeutics and radioisotopes is feasible for regional cancer treatment.
    • This localized radiochemotherapy approach shows potential for treating inoperable mammary tumors.
    • The technique may be adaptable for integration with other imaging modalities for enhanced therapeutic strategies.