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Surface energy and interparticle forces correlations in model pMDI formulations.

Daniela Traini¹, Philippe Rogueda, Paul Young

¹Pharmaceutical Technology Research Group, Department of Pharmacy, University of Bath, Bath, UK. r.price@bath.ac.uk

Pharmaceutical Research

|May 21, 2005

Summary

Particle interactions in pressurized metered dose inhalers (pMDIs) are better predicted by including polar surface free energy contributions. This approach enhances understanding of suspension stability for pMDIs.

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Area of Science:

Pharmaceutical Sciences
Materials Science
Physical Chemistry

Background:

Pressurized metered dose inhalers (pMDIs) rely on stable suspensions of drug particles.
Understanding particle interactions within propellants is crucial for pMDI efficacy.

Purpose of the Study:

To compare experimental particle cohesion/adhesion forces with theoretical interfacial free energy.
To characterize suspension stability in pMDIs.

Main Methods:

In situ atomic force microscopy (AFM) measured interparticulate forces in a model propellant.
Surface thermodynamic properties determined by contact angle (CA) and inverse gas chromatography (IGC).
Experimental data compared with theoretical work of adhesion/cohesion using a surface component approach (SCA).

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Main Results:

Dispersive surface free energies alone did not explain measured particle interaction forces.
A correlation was observed when polar interfacial interactions were included in the SCA model.

Conclusions:

Polar contributions to surface free energy are critical for particle interactions in propellant systems.
The SCA model, incorporating polar effects, shows potential for predicting pMDI suspension stability.