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Detection through screening of maternal thyrotoxicosis induced central hypothyroidism in newborns

Roy Joseph1, Yung Seng Lee, Steven Chin Yuen Ng

  • 1Department of Pediatrics, National University of Singapore.

The Southeast Asian Journal of Tropical Medicine and Public Health
|May 24, 2005
PubMed

Use of a third generation TSH assay enabled extremely low values of TSH to be detected through newborn screening. The use of a supplemental free thyroxine improved testing specificity. The hypothyroidism observed is believed to be secondary to suppression of the hypothalamic-pituitary-thyroid axis by placentally transferred maternal thyroxine.

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