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The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication
J A Coates1, N Cammack, H J Jenkinson
1Department of Virology, Glaxo Group Research Ltd., Greenford, Middlesex, United Kingdom.
Antimicrobial Agents and Chemotherapy
|January 1, 1992
Abstract:
Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.