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Updated: Aug 17, 2026

Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats
Published on: August 12, 2015
Simultaneous determination of vitamins C, B6 and PP in pharmaceutics using differential pulse voltammetry with a
Rosângela C Barthus1, Luiz H Mazo, Ronei J Poppi
1Instituto de Química de São Carlos, Universidade de São Paulo, P.O. Box 780, CEP 13560-970, São Carlos, SP, Brazil.
Abstract:
In this work, the artificial neural networks (ANN) and partial least squares (PLS) were applied to data obtained by differential pulse voltammetry for the determination of vitamins in synthetic and pharmaceutical samples. For calibration purposes, both synthetic and commercial samples were employed as standards. From the results it was possible to verify that ANN is the best method for modeling the data due to the fact that interactions among electro-active components result in non-linear response on the glassy carbon electrode. The results achieved for the determination of vitamins in pharmaceutical samples using ANN method provided a maximum value for relative error of 0.40% for VC, 8.3% for VPP and 9.1% for VB6. The proposed methodology is simple, rapid and can be easily used to control quality laboratories as an alternative analysis method.
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