Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydromorphone.

Alison Murray1, Neil A Hagen

  • 1Department of Family Medicine, Division of Palliative Medicine, University of Calgary, Calgary, Alberta, Canada.

Journal of Pain and Symptom Management
|May 24, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental evidence of life history trade-offs during ultra-endurance physical activity.

Evolutionary human sciences·2026
Same author

Myelin mapping in patients with rheumatoid arthritis-related fatigue: a TBSS-MTR study of integrity.

BJR open·2025
Same author

Postprandial Hypoglycemia in a Patient With Clinical Beckwith-Wiedemann Syndrome.

JCEM case reports·2025
Same author

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.

Wellcome open research·2024
Same author

Pituitary deficiencies related to optic nerve hypoplasia and visual acuity.

Clinical endocrinology·2024
Same author

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Nature genetics·2024
Same journal

Bereaved Parents and Spouses as Educators in Pediatric Simulation: Ethical Reflections.

Journal of pain and symptom management·2026
Same journal

The Unplugged Patient: A Case Report on Bridging the Digital Divide in Palliative Care.

Journal of pain and symptom management·2026
Same journal

Barriers perceived by palliative care fellowships in training physicians from diverse specialties.

Journal of pain and symptom management·2026
Same journal

Health Equity: Foundation of Serious Illness Care.

Journal of pain and symptom management·2026
Same journal

Coping with Breathlessness in Individuals with Lung Diseases: A Systematic Review and Meta-Synthesis.

Journal of pain and symptom management·2026
Same journal

Growing the Next Generation of Hospice and Palliative Medicine Researchers.

Journal of pain and symptom management·2026
See all related articles

Hydromorphone, an opioid analgesic, effectively manages various pain types. Further research is needed on its toxicity, use in nonmalignant pain, and metabolite roles.

Area of Science:

  • Pharmacology
  • Pain Management
  • Toxicology

Background:

  • Hydromorphone is a widely used semi-synthetic opioid for acute and chronic pain, including cancer pain.
  • Its pharmacokinetic and pharmacodynamic profiles are well-documented across various formulations and administration routes.
  • Metabolism yields inactive metabolites linked to neuroexcitation and toxicity.

Observation:

  • No evidence suggests hydromorphone has a higher abuse liability than other opioids.
  • Current research lacks comprehensive data on equianalgesic ratios and comparative toxicity risks.
  • Its application in chronic nonmalignant pain requires further investigation.

Findings:

  • Hydromorphone's efficacy in pain management is established.
  • Metabolites of hydromorphone are associated with potential neurotoxicity.

Related Experiment Videos

  • Abuse liability appears comparable to other opioids.

    • Implications:

    • Further research should clarify equianalgesic dosing and comparative opioid toxicity.
    • Investigating hydromorphone's role in nonmalignant pain is crucial.
    • Understanding the specific role of hydromorphone metabolites in toxicity, especially with organ failure, is essential.