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Fentanyl.

Theodore H Stanley1

  • 1University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.

Journal of Pain and Symptom Management
|May 24, 2005
PubMed
Summary
This summary is machine-generated.

Fentanyl remains the top perioperative opioid globally, despite newer alternatives. Its versatility and effectiveness ensure its continued use by anesthesiologists and pain physicians worldwide.

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Area of Science:

  • Anesthesiology and Pain Management
  • Pharmacology

Background:

  • Fentanyl, a potent synthetic opioid, was first synthesized over 40 years ago.
  • It is widely recognized for its lipid solubility and potent analgesic properties.

Observation:

  • Fentanyl is the most frequently utilized opioid in the perioperative setting globally.
  • Its application has expanded to various acute and chronic pain conditions over the past two decades.
  • Numerous novel drug delivery systems for fentanyl have been developed.

Findings:

  • Despite the emergence of alternative opioids with improved potency, safety profiles, and varied onset/duration characteristics, fentanyl maintains its primary role.
  • Anesthesiologists and Certified Registered Nurse Anesthetists consistently rely on fentanyl for perioperative pain management.

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  • Pain physicians globally continue to favor fentanyl for managing diverse pain conditions.

    • Implications:

    • Fentanyl's established efficacy and adaptability solidify its position as a cornerstone in perioperative care.
    • The ongoing development of delivery systems suggests a sustained focus on optimizing fentanyl's therapeutic utility.
    • Understanding fentanyl's enduring role is crucial for pain management strategies and pharmaceutical research.