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Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone
R V Omkumar1, A S Gaikwad, T Ramasarma
1Department of Biochemistry, Indian Institute of Science, Bangalore.
Biochemical and Biophysical Research Communications
|May 15, 1992
Abstract:
Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone indicating a possible feedback type of action.