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Updated: Aug 17, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
Myasthenia gravis: emerging new therapy options
1Department of Neurology, Geriatrics and Palliative Care, General Hospital, Grosse Parower St 47-53, Stralsund, 18410 Germany. j.sieb@klinikum-stralsund.de
Abstract:
Myasthenia gravis is probably the most thoroughly understood of all human autoimmune diseases. The basic mechanism of the disease is an antibody-mediated autoimmune attack that decreases the acetylcholine receptor density at the neuromuscular junction. Current therapies aim to restore the available acetylcholine receptors, deplete the autoantibodies or suppress the immune system. Prolonged drug treatment is required, but this carries a potential risk of severe adverse effects. Therefore, the ideal treatment for myasthenia would eliminate the abnormal autoimmune response without interfering with the immune system.
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