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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
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Genetical genomics in humans and model organisms
Dirk-Jan de Koning1, Chris S Haley
1The Roslin Institute, Roslin, Midlothian EH25 9PS, Scotland, UK. DJ.deKoning@BBSRC.ac.uk
Trends in Genetics : TIG
|May 24, 2005
Summary
Genetical genomics maps gene expression quantitative trait loci (eQTLs) for trait variation. While useful in model species, human studies show limitations, necessitating cautious interpretation and joint analysis for enhanced power.
Area of Science:
- Genetics
- Genomics
- Systems Biology
Background:
- Genetical genomics aims to identify loci controlling gene expression differences (eQTLs).
- These eQTLs may explain functional trait variation.
- Previous studies in model organisms demonstrate the approach's utility but have limitations.
Purpose of the Study:
- To review existing genetical genomics studies in model species.
- To analyze recent human genetical genomics studies.
- To explore the potential of joint analysis for more powerful insights.
Main Methods:
- Review of literature on genetical genomics in model species.
- Elaboration on two recent human genetical genomics studies.
- Discussion of comparative analysis and joint analysis strategies.
Main Results:
- Genetical genomics successfully demonstrates utility in model species.
- Current human studies have significant differences, complicating comparisons.
- Joint analysis of human experiments offers potential for increased statistical power.
Conclusions:
- Genetical genomics is a valuable tool for mapping eQTLs.
- Human studies require careful interpretation due to methodological variations.
- Combined analysis of human data can enhance the power of genetical genomics.
