Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Eosinophils and antitumour response].

R Costello1, T O'Callaghan, G Sébahoun

  • 1Département d'hématologie (Pr Gérard Sébahoun), hôpital Nord, chemin des Bourrelly, 13915 Marseille cedex 20, France. Regis.Costello@ap-hm.fr

La Revue De Medecine Interne
|May 24, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reactive oxygen species and aldehyde dehydrogenase 1A as prognosis and theragnostic biomarker in acute myeloid leukaemia patients.

Journal of cellular and molecular medicine·2024
Same author

High incidence of CDA deficiency in patients with hematological malignancies: perspectives and therapeutic implications.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

'Everything was just getting worse and worse': deteriorating job quality as a driver of doctor emigration from Ireland.

Human resources for health·2019
Same author

Hematopoietic reconstitution after autologous hematopoietic stem cell transplantation: do CD45 (+) CD34 (+) CD38 (-) progenitors really matter in real life?

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2018
Same author

Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12372 individuals 10-49 years old: a population-based study from the National Health and Nutrition Examination Survey.

Blood cancer journal·2017
Same author

ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment.

Oncogene·2017

Eosinophils may fight tumors by directly contacting cancer cells. Future immunotherapies could enhance this anti-tumor effect by attracting and activating eosinophils within the tumor microenvironment.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Context:

  • Tumor control involves immune responses, including cytotoxic T-lymphocytes and natural killer (NK) cells.
  • Eosinophils, typically involved in allergies and parasitic infections, are increasingly associated with various cancers.
  • Tumor-associated tissue eosinophilia (TATE) is often a favorable prognostic indicator, except in Hodgkin's disease.

Purpose:

  • To explore the potential role of eosinophils in anti-tumor immune responses.
  • To investigate the mechanisms by which eosinophils might contribute to cancer control.

Summary:

  • Eosinophils' anti-tumor effects depend on their close proximity to tumor cells.
  • Tumor-associated tissue eosinophilia (TATE) is a significant prognostic factor in many cancers.

Related Experiment Videos

  • In Hodgkin's disease, eosinophils may promote tumor cell survival through specific signaling pathways.

    • Impact:

    • Future immunotherapies could leverage eosinophils for cancer treatment.
    • Strategies may involve direct cytokine injection or expression vectors to activate eosinophils within tumors.
    • Targeting eosinophil-mediated anti-tumor immunity offers a novel therapeutic avenue.