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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
responses of mycobacterium tuberculosis to growth in the mouse lung
Eugenie Dubnau1, John Chan, V P Mohan
1The Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA.
Infection and Immunity
|May 24, 2005
Abstract:
Using a promoter trap, we have identified 56 Mycobacterium tuberculosis genes preferentially expressed in the mouse lung. Quantitative real-time PCR showed that RNA levels of several genes were higher from bacteria growing in mouse lungs than from broth cultures. These results support the current hypothesis that Mycobacterium tuberculosis utilizes fatty acids as a carbon source in the mouse lung.
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