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Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection
Published on: September 18, 2020
Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages
Mauro Oddo1, Thierry Calandra, Richard Bucala
1Medical Critical Care Division, University Hospital, CH-1011 Lausanne, Switzerland. mauro.oddo@chuv.hospvd.ch
Infection and Immunity
|May 24, 2005
Abstract:
Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.
