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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
The radiology of chronic lung disease in children
1Great Ormond Street Children's Hospital, Great Ormond Street, London WC1N 3JH, UK.
Insights
Chronic lung disease (CLD) in children is a complex group of conditions. Increased survival of premature infants and advanced respiratory support contribute to its rising prevalence, with common causes including cystic fibrosis and bronchopulmonary dysplasia.
Area of Science:
- Pediatrics
- Pulmonology
- Neonatology
Background:
- Chronic lung disease (CLD) in children encompasses diverse clinicopathological conditions.
- CLD prevalence is rising due to improved survival rates in preterm infants and advanced respiratory support.
- These disorders typically progress slowly over extended periods.
Purpose of the Study:
- To provide an overview of the heterogeneous nature of pediatric chronic lung disease.
- To highlight the increasing prevalence and common etiologies of CLD in children.
- To categorize the main clinicopathological entities contributing to CLD.
Main Methods:
- Literature review of pediatric chronic lung disease.
- Analysis of epidemiological trends in pediatric respiratory disorders.
- Categorization of common causes of CLD in pediatric populations.
Main Results:
- Pediatric CLD is a spectrum of diseases, not a single entity.
- Key contributors to CLD include cystic fibrosis (CF), bronchiectasis, and bronchopulmonary dysplasia (BPD).
- Other significant causes identified are asthma, chronic aspiration, and constrictive obliterative bronchiolitis.
Conclusions:
- Understanding the heterogeneity of pediatric CLD is crucial for effective management.
- The rise in CLD is linked to advancements in neonatal care and improved survival.
- Common pediatric CLD causes necessitate targeted diagnostic and therapeutic strategies.
Abstract:
Chronic lung disease (CLD) in children represents a heterogeneous group of many distinct clinicopathological entities. The prevalence of CLD has increased in the past decade because of the more advanced and intensive respiratory support provided for compromised children and additionally the overall improved survival of preterm babies. The disorders which constitute CLD generally have a slow tempo of progression over many months or even years. The most common causes of CLD in children are cystic fibrosis (CF), and other causes of bronchiectasis (such as immunodeficiency, and in the third world, post-infective bronchiectasis, for example, measles), bronchopulmonary dysplasia (BPD) (or lung disease of prematurity), asthma, chronic gastro-oesophageal reflux/aspiration pneumonitis, and constrictive obliterative bronchiolitis.
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