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Related Experiment Videos

Neoplastic meningitis.

Marc C Chamberlain1

  • 1Department of Neuro-Oncology, University of S Florida, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Dr, Suite 3136, Tampa, FL 33612, USA. chambemc@moffitt.usf.edu

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|May 24, 2005
PubMed
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Neoplastic meningitis (NM), a common neuro-oncology issue, affects the entire nervous system. Treatment involves radiation and intra-CSF chemotherapy, offering palliative stabilization for patients with CNS metastases.

Area of Science:

  • Neuro-oncology
  • Oncology
  • Neurology

Background:

  • Neoplastic meningitis (NM) affects 5% of cancer patients, representing the third most common site of CNS metastases.
  • NM involves the entire neuraxis, leading to diverse clinical manifestations affecting the spine, cranial nerves, and cerebral hemispheres.
  • Craniospinal disease involvement necessitates comprehensive staging and treatment across all cerebrospinal fluid (CSF) compartments.

Purpose of the Study:

  • To review the common problem of neoplastic meningitis (NM) in neuro-oncology.
  • To outline the current treatment strategies for NM.
  • To discuss the role of systemic therapy and intra-CSF drug delivery in managing NM.

Main Methods:

  • Review of current literature on neoplastic meningitis.

Related Experiment Videos

  • Discussion of treatment modalities including radiotherapy and intra-CSF chemotherapy.
  • Analysis of the impact of systemic therapy on NM management.

    • Main Results:

    • NM is a common complication of cancer with widespread neurological effects.
    • Treatment involves involved-field radiotherapy and intra-CSF drug therapy (methotrexate, cytarabine, thiotepa).
    • Concomitant systemic therapy may improve outcomes and potentially reduce the need for intra-CSF chemotherapy.

    Conclusions:

    • Neoplastic meningitis requires a treatment approach encompassing the entire neuraxis.
    • Current intra-CSF therapies are limited but offer palliative stabilization.
    • Systemic therapy holds promise for improving patient outcomes in NM.