Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vector-mediated cancer gene therapy: an overview.

Prem Seth1

  • 1Laboratory of Gene Therapy, ENH Research Institute,Evanston Hospital; Northwestern University, Evanston, IL 60201, USA. pseth@northwestern.edu

Cancer Biology & Therapy
|May 24, 2005
PubMed
Summary

Gene therapy offers novel cancer treatments by targeting oncogenesis mechanisms. This review details gene therapy strategies and delivery vectors for improved cancer care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Call for Special Issue Papers:</i> Oncolytic Viruses and Cancer Immunotherapy.

Human gene therapy·2020
Same author

<i>Call for Special Issue Papers:</i> Oncolytic Viruses and Cancer Immunotherapy.

Human gene therapy·2020
Same author

<i>Call for Special Issue Papers:</i> Oncolytic Viruses and Cancer Immunotherapy.

Human gene therapy·2020
Same author

LyP-1-Modified Oncolytic Adenoviruses Targeting Transforming Growth Factor β Inhibit Tumor Growth and Metastases and Augment Immune Checkpoint Inhibitor Therapy in Breast Cancer Mouse Models.

Human gene therapy·2020
Same author

Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice.

Cancer gene therapy·2020
Same author

Oncolytic adenovirus targeting TGF-β enhances anti-tumor responses of mesothelin-targeted chimeric antigen receptor T cell therapy against breast cancer.

Cellular immunology·2020

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Significant advancements in understanding cancer's molecular basis have fueled gene therapy development.
  • The creation of effective DNA delivery systems (vectors) is crucial for gene therapy applications.

Purpose of the Study:

  • To review diverse cancer gene therapy strategies.
  • To examine various viral and non-viral vectors used for gene delivery in cancer treatment.

Main Methods:

  • Review of established and emerging gene therapy approaches.
  • Analysis of commonly employed viral vectors (retroviral, adenoviral, AAV, pox, herpes simplex, HIV-based) and non-viral vectors.
  • Discussion of targetable vectors for enhanced specificity.

Main Results:

  • Comprehensive overview of strategies including tumor suppressor gene transfer, suicide gene therapy, oncogene inhibition, immunomodulation, and modulation of angiogenesis, invasion, and metastasis.
  • Detailed examination of vector systems for delivering therapeutic genes.
  • Exploration of chemosensitization, radiosensitization, and stem cell chemoprotection approaches.

Conclusions:

  • Cancer gene therapy presents a promising frontier with multiple strategic avenues.
  • The choice of vector significantly impacts therapeutic efficacy and safety.
  • Ongoing research into challenges and future directions is vital for clinical translation.

Related Experiment Videos