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Does maternal hypoglycemia during screening glucose assessment identify a pregnancy at-risk for adverse perinatal
Jeffrey H Feinberg1, Everett F Magann, John C Morrison
1Department of Family Practice, Naval Hospital, Camp Pendleton, Camp Pendleton, CA, USA.
Objective:
To determine the perinatal outcome in pregnancies with maternal hypoglycemia following a second trimester oral glucose challenge test (GCT).
Study Design:
Retrospective case-control study of pregnancies undergoing a second trimester 1-hour oral glucose challenge test (GCT). Hypoglycemic pregnancies (<88 mg/dl) were matched with pregnancies with 1-hour glucoses of >88 mg/dl. Antepartum, intrapartum, and neonatal outcomes were assessed.
Results:
Over 29 months, 334 hypoglycemic singleton pregnancies were matched with 334 controls. A greater number of special/neonatal intensive care unit (SCN/NICU) admissions occurred in the hypoglycemic group (48/334 (14.4%) vs 29/334 (8.7%) in the control group) (p=0.02). The SCN/NICU admission rate remained after controlling for maternal hypertension, smoking, and preterm birth (p=0.037). The development of pregnancy-induced hypertension in women with hypoglycemia 24/334 (7.2%) compared with euglycemic women 13/334 (3.9%, p<0.06) was not significant.
Conclusion:
Admission to SCN/NICU is increased in pregnant women with hypoglycemia following a GCT.
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