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[Miller-Fisher syndrome].
Lisa Jørgensen1, Christian A Vedeler
1Nevrologisk avdeling, Haukeland Universitetssykehus, 5021 Bergen. joergensenlisa@hotmail.com
Summary
Miller-Fisher syndrome, a Guillain-Barré syndrome variant, presents with ophthalmoplegia, ataxia, and areflexia. Anti-GQ1b antibodies are key, with patients often recovering fully after treatment.
Area of Science:
- Neurology
- Immunology
Background:
- Miller-Fisher syndrome (MFS) is a rare variant of Guillain-Barré syndrome.
- MFS is characterized by ophthalmoplegia, ataxia, and areflexia.
- Anti-ganglioside GQ1b antibodies are implicated in approximately 90% of MFS cases.
Observation:
- Two patients with Miller-Fisher syndrome were studied.
- Both patients presented with the classic triad of MFS symptoms.
- Both patients had antibodies against GQ1b.
Findings:
- Miller-Fisher syndrome patients often experience upper respiratory tract infections preceding symptom onset.
- One patient exhibited a severe form of MFS with bulbar signs, requiring plasma exchange.
- Both patients achieved near-complete recovery within months.
Implications:
- GQ1b antibodies play a significant role in the pathogenesis of Miller-Fisher syndrome.
- Plasma exchange can be an effective treatment for severe MFS cases.
- Early diagnosis and treatment facilitate favorable patient outcomes in MFS.