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Updated: Aug 17, 2026

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
Published on: February 3, 2026
High-dose misoprostol used in outpatient management of first trimester spontaneous abortion
Stavros Sifakis1, Emmanuel Angelakis, Elpida Vardaki
1Department of Obstetrics and Gynecology, University of Crete, 71201 Voutes, Heraklion, Crete, Greece. sifakis@excite.com
Aim:
The aim of this study was to evaluate the efficacy and tolerance of a high dose of vaginal misoprostol for outpatient medical management of missed abortion.
Methods:
Three doses of 400 mug misoprostol were administered intravaginally every 4 h daily, for a maximum period of 3 days, to 108 women with uneventful first trimester pregnancy failure.
Results:
A total of 98 women (90.7%) were managed successfully, with 74 (68.5%) of them within the first 24 h. The mean dose of misoprostol administered was 1,113.0 microg (range 400-3,600 microg), and the mean time required was 19.5 h (range 7-65 h). Only 6 out of 108 women (9.3%) required surgical intervention as the result of retained products of conception. The side effect profile was minimal.
Conclusion:
This protocol of 400 mug intravaginally misoprostol every 4 h as three daily doses for a maximum of 3 days, may offer an efficacious and safe alternative to the outpatient management of first-trimester missed abortion.
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