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Related Experiment Videos

Type I polyketide synthases may have evolved through horizontal gene transfer.

Aurélien Ginolhac1, Cyrille Jarrin, Patrick Robe

  • 1LibraGen S.A., Bâtiment Canal Biotech 1, 3 rue des Satellites, 31400, Toulouse, France. contact@libragen.com

Journal of Molecular Evolution
|May 24, 2005
PubMed
Summary

Horizontal gene transfers among actinomycetales species likely explain the homogeneity of this bacterial group. These transfers of Type I polyketide synthase (PKS I) genes may mimic vertical inheritance patterns.

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Area of Science:

  • Biochemistry and Molecular Biology
  • Microbial Genetics
  • Natural Product Biosynthesis

Background:

  • Type I polyketide synthases (PKS I) are crucial modular enzymes in synthesizing valuable natural products.
  • Each PKS I module typically comprises ketosynthase (KS), acyltransferase (AT), and acyl carrier protein domains.

Purpose of the Study:

  • To investigate the evolutionary history of PKS I genes within actinomycetales.
  • To explore the role of horizontal gene transfer (HGT) in shaping the PKS I gene repertoire and bacterial genome evolution.

Main Methods:

  • Phylogenetic analysis of the ketosynthase (KS) domain from 23 PKS I clusters.
  • Comparative genomics to infer gene transfer events.

Main Results:

Related Experiment Videos

  • Phylogenetic analysis revealed extensive horizontal gene transfer of PKS I genes among actinomycetales species.
  • Evidence suggests HGT contributes significantly to the observed homogeneity and robustness of the actinomycetales group.
  • Gene transfer events between closely related species can resemble vertical inheritance patterns.

Conclusions:

  • Horizontal gene transfer is a major evolutionary force in actinomycetales, impacting the distribution and evolution of PKS I genes.
  • The linear and unstable nature of actinomycetales chromosomes, along with mobile genetic elements, likely facilitates HGT.
  • Understanding HGT in PKS I evolution provides insights into bacterial genome plasticity and natural product diversity.