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Updated: Aug 17, 2026

MRI and PET in Mouse Models of Myocardial Infarction
Published on: December 19, 2013
[Study of myocardial viability: comparison of PET and MRI]
Aloha Meave1, Alejandro Ricalde, Carlos Sierra Fernández
1Departamento de Resonancia Magnética, Instituto Nacional de Cardiología Ignacio Chávez", México, DF.
Background:
In the last years, few methods for the assessment of myocardial viability have been developed. Now a days the gold standard test for this purpose is the Positron Emission Tomography (PET). Recently, the expansion of Cardiovascular Magnetic Resonance imaging (MRI) has promoted the research for indexes or scores than can predict myocardial viability; so far, the late enhancement has proved to be one of the most accurate scores. The purpose of this study is to establish a correlation between the information of PET with the results of MRI in the assessment of myocardial viability. Late enhancement patterns and segmental mobility were compared. Sensitivity, specificity and positive and negative predictive values were calculated. SPSS v. 10 program was used for the statistic analysis.
Methods:
17 patients with diagnosis of myocardial infarction were enrolled. All of them underwent into a myocardial viability detection PET study and into a cardiovascular magnetic resonance study using a late enhancement technique. Results were interpreted by experts. The 17 segments model of The American Heart Association was used.
Results:
A total of 289 myocardial segments were analyzed, by PET 239 (82%) viable segments and 50 (17.3%) of non viable segments were detected, meanwhile by MRI 210 (72.6%) and 79 (27.4%) of viable and non viable myocardial segments respectively were found. Both techniques correlate 75% of the times and when vascular territories were analyzed, a good correlation was also established.
Conclusions:
MRI is an adequate technique to determine viability since it has good correlation with PET. This is the first study realized in Latin America that compares PET and MRI in the diagnosis of myocardial viability.
Insights
Cardiovascular Magnetic Resonance imaging (MRI) shows good correlation with Positron Emission Tomography (PET) for assessing myocardial viability. This study validates MRI as an adequate technique for determining heart muscle viability post-infarction.
Area of Science:
- Cardiology
- Medical Imaging
- Diagnostic Techniques
Background:
- Assessing myocardial viability is crucial after infarction.
- Positron Emission Tomography (PET) is the current gold standard.
- Cardiovascular Magnetic Resonance imaging (MRI) with late enhancement shows promise.
Purpose of the Study:
- To correlate PET findings with MRI results for myocardial viability assessment.
- To compare late enhancement patterns and segmental mobility between PET and MRI.
- To evaluate the diagnostic accuracy of MRI against PET.
Main Methods:
- 17 patients with myocardial infarction underwent both PET and MRI viability studies.
- Late enhancement technique was used in MRI.
- The American Heart Association's 17-segment model was applied.
Main Results:
- Analysis of 289 myocardial segments revealed differences in viability detection between PET (82% viable) and MRI (72.6% viable).
- Overall correlation between PET and MRI was 75%.
- Good correlation was also observed when analyzing vascular territories.
Conclusions:
- MRI is a suitable technique for assessing myocardial viability, demonstrating good correlation with PET.
- This study represents the first comparison of PET and MRI for myocardial viability in Latin America.
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