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Updated: Aug 17, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Palliation of heart failure
Mellar P Davis1, Nancy M Albert, James B Young
1The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA.
Insights
Stage D heart failure significantly impacts morbidity and mortality, often exceeding that of many cancers. Palliative care and cardiology collaboration are essential for managing these severe heart failure symptoms.
Area of Science:
- Cardiology
- Palliative Care
- Heart Failure Pathophysiology
Background:
- Heart failure is a leading cause of death and illness in the US.
- Stage D heart failure presents severe symptoms and high mortality rates, comparable to advanced cancers.
- Understanding heart failure pathophysiology has evolved, revealing links to ventricular remodeling and neurohumoral responses.
Purpose of the Study:
- To highlight the critical need for palliative care in advanced heart failure (Stage D).
- To emphasize the importance of interdisciplinary collaboration between cardiology and palliative care specialists.
- To underscore the necessity of palliative strategies for highly symptomatic Stage D heart failure patients.
Main Methods:
- Review of current understanding of Stage D heart failure pathophysiology.
- Analysis of evolving drug classes targeting ventricular remodeling and neurohumoral responses.
- Discussion on the role of palliative care in conjunction with existing therapies.
Main Results:
- Despite advancements in drug and device therapies, Stage D heart failure management still requires palliative interventions.
- Collaboration between cardiology and palliative care specialists can improve symptom management.
- Interdisciplinary approaches form the foundation for effective research in advanced heart failure.
Conclusions:
- Stage D heart failure demands integrated palliative care strategies.
- Enhanced collaboration between cardiology and palliative care is crucial for improving patient outcomes.
- Further research is needed to optimize palliative care in advanced heart failure.
Abstract:
Heart failure is the major cause of morbidity and mortality in the United States. Stage D heart failure has a greater mortality rate than many cancers and has equivalent symptom burden and severity. There has been a paradigm shift in our understanding of the pathophysiology of heart failure. Progressive heart failure is associated with ventricular remodeling and a maladaptive neurohumoral response. Drug classes have evolved that curtail ventricular remodeling, and blunt neurohumoral responses reduce morbidity and mortality. Despite combination drug and device therapies, the management of Stage D heart failure includes palliation. Both cardiology and palliative specialists need to learn from one another in order to palliate these highly symptomatic patients. Such collaboration will enhance care and are the basis for well-conceived research trials.
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