Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis and programmed cell death in immunity.

J J Cohen1, R C Duke, V A Fadok

  • 1Department of Microbiology and Immunology, University of Colorado Medical School, Denver 80262.

Annual Review of Immunology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Equine allergic skin diseases: Clinical consensus guidelines of the World Association for Veterinary Dermatology.

Veterinary dermatology·2023
Same author

Special-Fed Veal: Separable components, proximate composition, and nutrient analysis of selected raw and cooked, wholesale and retail cuts.

Meat science·2018
Same author

Methodological issues in behavioural immunology.

Immunology today·2014
Same author

Overcoming the perceived barriers to health care access among single mothers in coastal Kenya.

International journal of public health·2013
Same author

Chicken pox with simultaneous idiopathic thrombocytopenic purpura; report of a case.

The New England journal of medicine·2010
Same author

Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release.

Cell death and differentiation·2005

Programmed cell death, known as apoptosis, is essential in the mammalian immune system, particularly during lymphocyte development and antigen response. This process involves specific cellular changes and rapid disposal by phagocytes.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Programmed cell death is a fundamental biological process in mammals.
  • The immune system extensively utilizes programmed cell death, especially in lymphocyte development and response to antigens.

Purpose of the Study:

  • To investigate the phenomenon of programmed cell death, specifically apoptosis, within the mammalian immune system.
  • To describe the morphological characteristics and mechanisms of apoptosis.

Main Methods:

  • Observation of cellular morphological changes during apoptosis, including shrinkage, zeiosis, nuclear collapse, and chromatin cleavage.
  • Analysis of the role of phagocytes in clearing apoptotic cells.
  • Investigation into the requirement of macromolecular synthesis in some apoptotic cases.
  • Examination of how cytotoxic T cells induce apoptosis in target cells.

Related Experiment Videos

Main Results:

  • Apoptosis is characterized by distinct morphological features such as cell shrinkage and nuclear fragmentation.
  • Apoptotic cells are efficiently cleared by phagocytes, preventing cellular content release.
  • New macromolecular synthesis is not universally required for apoptosis to occur.
  • Cytotoxic T cells can induce apoptosis in target cells.

Conclusions:

  • Apoptosis is a critical, morphologically defined process in the immune system.
  • The precise mechanisms underlying apoptosis are an active area of research.