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[Molecular machinery of the transcription initiation by RNA polymerase II]

Iu V Shidlovskiĭ, P V Mardanov, O N Fedorova

    Genetika
    |May 25, 2005
    PubMed

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    Eukaryotic RNA Polymerases00:58

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    General Transcription Factors01:30

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    Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...