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Related Experiment Videos

A single solution for multiple organ procurement and preservation.

Georges Karam1, Philippe Compagnon, Maryvonne Hourmant

  • 1Pôle Néphrologie-Urologie-Transplantation, Hôtel Dieu, Centre Hospitalier Universitaire de Nantes, Nantes, France.

Transplant International : Official Journal of the European Society for Organ Transplantation
|May 25, 2005
PubMed
Summary
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Celsior solution effectively preserves thoracic and abdominal organs for transplantation. This study shows its safety and efficacy in multiple organ procurement, leading to good patient and graft survival rates.

Area of Science:

  • Transplantation Medicine
  • Organ Preservation
  • Surgical Innovation

Background:

  • Standard organ preservation methods often involve multiple solutions.
  • Evaluating single-solution efficacy for multi-organ procurement is crucial for optimizing transplant logistics.

Purpose of the Study:

  • To assess the safety and efficacy of Celsior solution for flushing and cold storage of both thoracic and abdominal organs.
  • To determine the performance of Celsior in a multi-center setting for multiple organ procurement.

Main Methods:

  • Prospective, multi-center, noncomparative study.
  • Utilized Celsior (solution S) as the sole flushing and cold storage solution in 72 multiple-organ procurements.
  • Evaluated outcomes in 264 implanted grafts (kidneys, pancreases, livers, hearts, heart-lungs).

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Main Results:

  • Successful implantation of 264 grafts with varying cold ischemia times.
  • Favorable 12-month patient and graft survival rates across all organ types.
  • Delayed graft function in 14% of kidney recipients; 1 liver recipient experienced primary nonfunction.
  • Low rates of cardiac complications and good early recovery for heart recipients.

Conclusions:

  • Celsior is a safe and effective ready-to-use solution for simultaneous procurement and preservation of thoracic and abdominal organs.
  • Its use simplifies the procurement process while maintaining excellent graft viability and patient outcomes.
  • Further supports Celsior as a viable option for multi-organ transplantation protocols.