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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Complexation of fluoxetine hydrochloride with beta-cyclodextrin. A proton magnetic resonance study in aqueous
Syed Mashhood Ali1, Fahmeena Asmat, Arti Maheshwari
1Department of Chemistry, Aligarh Muslim University, Aligarh 202002, UP, India. smashhoodali@yahoo.com
Abstract:
A proton magnetic resonance spectroscopic study in D2O of mixtures of fluoxetine hydrochloride (guest) with beta-cyclodextrin (host) revealed the existence of two different equilibria for 1:1 inclusion complexes in which -CF3 substituted ring of the guest is more tightly held by the host cavity. The structures of the two complexes have been proposed which are supported by 2DROESY spectral data. The dissociation constant was also determined.

