Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Impaired lung function and subclinical atherosclerosis. The ARIC Study.

Emily B Schroeder1, Verna Lamar Welch, Gregory W Evans

  • 1Duke University School of Medicine, Durham, NC 27705, USA.

Atherosclerosis
|May 25, 2005
PubMed
Summary

Reduced lung function, measured by forced expiratory volume (FEV1), is linked to atherosclerosis markers like ankle-brachial index and carotid intima-media thickness. This association persists even in non-smokers, suggesting complex links beyond smoking.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness.

medRxiv : the preprint server for health sciences·2025
Same author

The Effect of Interventions to Prevent Type 2 Diabetes on the Development of Diabetic Retinopathy: The DPP/DPPOS Experience.

Diabetes care·2025
Same author

Peripheral artery disease and risk of kidney outcomes: The Atherosclerosis Risk in Communities (ARIC) study.

Atherosclerosis·2024
Same author

Maximum likelihood estimation for semiparametric regression models with interval-censored multistate data.

Biometrika·2024
Same author

Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification.

Nature cardiovascular research·2024
Same author

Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology.

Neurology·2024

Area of Science:

  • Cardiovascular disease research
  • Pulmonary medicine
  • Epidemiology

Background:

  • Reduced pulmonary function is associated with increased atherosclerotic vascular events.
  • Mechanisms are unclear, and the link is observed in non-smokers.
  • Limited research exists on subclinical atherosclerosis and lung function.

Purpose of the Study:

  • To investigate the cross-sectional association between lung function and subclinical atherosclerosis markers.
  • To examine these relationships in a large adult cohort, stratified by smoking status.

Main Methods:

  • Utilized data from 14,000 adults in the ARIC Study.
  • Measured lung function via forced expiratory volume in 1s (FEV1).
  • Assessed subclinical atherosclerosis using ankle-brachial index (ABI), carotid intimal-medial thickness (IMT), and carotid plaques.

Related Experiment Videos

Main Results:

  • Decreased FEV1 correlated with lower ABI and higher IMT across all smoking groups.
  • The ABI association remained after adjusting for cardiovascular disease risk factors.
  • The IMT association was attenuated by risk factor adjustment, disappearing in never-smokers.
  • No association was found between FEV1 and carotid plaques.

Conclusions:

  • A complex relationship exists between FEV1 and atherosclerotic vascular disease.
  • Findings suggest potential shared pathways or FEV1 as an independent marker.
  • Further research is warranted to elucidate these mechanisms.