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Aging and microwave effects on alginate/chitosan matrices.
Tin Wui Wong1, Lai Wah Chan, Shyan Bin Kho
1Faculty of Pharmacy, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia.
Summary
Microwave irradiation influences drug release from alginate, alginate-chitosan, and chitosan beads. The polymer matrix
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Polymer Chemistry
Background:
- Drug delivery systems often utilize polymer beads for controlled release.
- Alginate, chitosan, and their composites are common materials for bead preparation.
- The effect of aging and external stimuli like microwave irradiation on drug release needs further investigation.
Purpose of the Study:
- To investigate the impact of microwave irradiation on the drug release characteristics of freshly prepared and aged alginate, alginate-chitosan, and chitosan beads.
- To understand how microwave treatment affects drug-polymer interactions and polymer crosslinkage.
- To evaluate the stability and release profiles of sulphathiazole from these beads under various conditions.
Main Methods:
- Beads containing sulphathiazole were prepared using the extrusion method.
- Dried beads were exposed to microwave irradiation at 80 W for varying durations (10 min, 20 min, or cycles).
- Drug dissolution, content, stability, polymorphism, drug-polymer interaction, and polymer crosslinkage were analyzed using techniques like dissolution testing, DSC, and FTIR spectroscopy.
Main Results:
- Chemical stability of the drug within the beads was unaffected by microwave irradiation or storage time.
- Drug release was primarily governed by the extent of polymer interaction within the beads.
- Aged alginate beads required multiple microwave cycles for a drug release retarding effect, unlike fresh beads.
- Microwave irradiation (10 min) significantly enhanced the drug release retarding property of aged alginate-chitosan beads.
- Aged chitosan beads showed increased drug release after microwave treatment, despite higher polymer interaction.
Conclusions:
- The molecular arrangement of polymer chains in the matrix significantly influences its response to microwave irradiation for inducing drug release retarding properties.
- Microwave irradiation can be a tool to modulate drug release from polymer beads, with effects varying based on polymer type, age, and irradiation parameters.
- Understanding these interactions is crucial for designing effective and stable drug delivery systems.