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Updated: Aug 17, 2026

Isolation of Atrial Myocytes from Adult Mice
Published on: July 25, 2019
Neuronal regulation and function of natriuretic peptide receptor C
1Department of Pharmacology, University of Minnesota-Duluth, School of Medicine, 1036 University Drive, Duluth, MN 55812, USA. gtracht1@d.umn.edu
Abstract:
The neuromodulatory effect of natriuretic peptides is probably the best example of a whole organ response mediated by natriuretic peptide C receptors (NPR-Cs). Both NPR-C specific agonists and ablation experiments utilizing NPR-C specific antibodies or antisense oligonucleotides demonstrated the essential signaling role of the NPR-C in these neuromodulatory responses. Our most recent studies utilize peptides representing the NPR-C intracellular region to elucidate the specific signaling region of the NPR-C. These studies have identified an inhibitory influence of NPR-C on adrenergic neurotransmission by a calcium-dependent process.
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