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Discovery of selective aldo-keto reductase ligands--an on-bead assay strategy

Seth Dixon1, Lori Robins, Robert A Elling

  • 1Department of Chemistry, University of California, Davis, 95616-5295, USA.

Bioorganic & Medicinal Chemistry Letters
|May 25, 2005
PubMed

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Reduction is a simple strategy to convert a carbonyl group to a hydroxyl group. The three major pathways to reduce carbonyls to alcohols are catalytic hydrogenation, hydride reduction, and borane reduction.
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...