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Published on: February 15, 2016
Flow injection spectrofluorimetric study of the supramolecular interaction between beta-cyclodextrin and dequalinium
Bo Tang1, Baoxiu Jia, Xifeng Shi
1College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, PR China. tangb@sdnu.edu.cn
Abstract:
The supramolecular interaction of dequalinium chloride (DQC) and beta-cyclodextrin has been studied by flow injection spectrofluorimetry. The results showed that beta-CD reacted with DQC to form a 1:1 host:guest complex with an apparent association constant of 4.99 x 10(2) L mol(-1). Based on the enhancement of the fluorescence intensity of DQC, a flow injection spectrofluorometric method for the determination of DQC in bulk aqueous solution in the presence of beta-CD was developed. The linear range was 0.0412-30.00 microg mL(-1). The detection limit was 12.3 ng mL(-1) with a sampling rate of 80 h(-1). There was no interference from the excipients normally used in tablets and serum compositions. The proposed method was successfully applied to the determination of DQC in tablets and serum.
