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Hardy-Weinberg testing of a single homozygous genotype
John J Chen1, Tao Duan, Richard Single
1Department of Preventive Medicine, State University of New York, Stony Brook, New York 11794, USA. john.chen@stonybrook.edu
Abstract:
No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. chi2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed.
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