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Updated: Aug 17, 2026

Cell-Free DNA Integrity Analysis in Urine Samples
Published on: January 5, 2017
Evaluation of urinary PrPSc as a diagnostic test for sporadic, variant, and familial CJD
M W Head1, E Kouverianou, L Taylor
1National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, UK. m.w.head@ed.ac.uk
Abstract:
Previously collected urine specimens from 100 patients referred to the UK National CJD Surveillance Unit as suspected cases of Creutzfeldt-Jakob disease (CJD) were analyzed, testing for abnormal prion protein (PrP(Sc)). In this context, the test had a low sensitivity and was not completely specific for CJD. Additionally, the proteins detected by this assay were not PrP(Sc) but appeared to be immunoglobulins.
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