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Gas chromatographic/mass spectrometric identification of 3-hydroxydicarboxylic acids in urine
B J Verhaeghe1, J F Van Bocxlaer, A P De Leenheer
1Laboratoria voor Medische Biochemie en Klinische Analyse, Rijksuniversiteit Gent, Belgium.
Biological Mass Spectrometry
|January 1, 1992
Abstract:
Organic acid profiles were routinely analysed for two patients suffering from a massive 3-hydroxydicarboxyluria and five patients suffering from ketoaciduria. The identification of the urinary, saturated and unsaturated 3-hydroxydicarboxylic acids as their trimethylsilyl derivatives was performed with electron impact and positive chemical ionization gas chromatography/mass spectrometry. Additionally, their methylene units have been determined on SE-52 and OV-1701 types of stationary phases.