Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics and cancer.

M A Pierotti1, T A Dragani

  • 1Istituto Nazionale Tumori, Milan, Italy.

Current Opinion in Oncology
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Genetic research reveals tumor suppressor genes are key in inherited and sporadic cancers. Understanding these genes, like p53, aids in identifying cancer susceptibility and developing targeted therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In silico prediction of the interaction of legacy and novel per- and poly-fluoroalkyl substances (PFAS) with selected human transporters and of their possible accumulation in the human body.

Archives of toxicology·2024
Same author

Difficulties in establishing a causal link between chemical exposures and cancer cannot be overcome by court assessments.

Human & experimental toxicology·2020
Same author

Genetic mapping of the homeobox-containing gene Otxl gene on mouse Chromosome 11.

Mammalian genome : official journal of the International Mammalian Genome Society·2016
Same author

Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc.

British journal of cancer·2016
Same author

Are strong opioids equally effective and safe in the treatment of chronic cancer pain? A multicenter randomized phase IV 'real life' trial on the variability of response to opioids.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

A subset of genetic susceptibility variants for colorectal cancer also has prognostic value.

The pharmacogenomics journal·2015
Same journal

Artificial intelligence-augmented robotic surgery in gynecologic oncology: intraoperative assistance and analytics.

Current opinion in oncology·2026
Same journal

Artificial intelligence in cervical cancer screening and triage: a role-stratified systematic review and bivariate meta-analysis.

Current opinion in oncology·2026
Same journal

Deep learning assisting the surgical management of gynecologic cancers.

Current opinion in oncology·2026
Same journal

Pain management in pancreatic cancer: time to change our strategy!

Current opinion in oncology·2026
Same journal

Systemic radionuclide treatments in gastro-entero-pancreatic neuroendocrine tumours.

Current opinion in oncology·2026
Same journal

5-Fluorouracil at seventy: still attractive but barely understood. A cautionary tale for drug development.

Current opinion in oncology·2026
See all related articles

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Significant advancements in understanding cancerogenesis and genetic susceptibility to cancer have been made.
  • The role of tumor suppressor genes in both inherited and sporadic cancers, including childhood tumors, is increasingly recognized.
  • The identification of specific gene defects in inherited cancer syndromes provides crucial insights.

Purpose of the Study:

  • To explore the role of tumor suppressor genes in various cancer types.
  • To investigate the genetic determinants of cancer susceptibility.
  • To highlight the significance of gene defects in inherited cancer syndromes.

Main Methods:

  • Review of recent findings in cancer genetics.
  • Identification and characterization of specific genes involved in cancer syndromes.

Related Experiment Videos

  • Analysis of genetic susceptibility models in mice.

    • Main Results:

    • Germline mutation in the tumor suppressor gene p53 identified as the cause of Li-Fraumeni syndrome.
    • Cloning and partial characterization of genes associated with neurofibromatosis type I (NF-1) and familial adenomatous polyposis.
    • Recognition of genes involved in DNA repair and carcinogen metabolism as factors influencing overall cancer risk.

    Conclusions:

    • Tumor suppressor genes play a critical role in both inherited and sporadic cancers.
    • Understanding genetic mutations is vital for identifying cancer predisposition.
    • Murine models offer a valuable approach for uncovering the genetic basis of cancer susceptibility.